AKT1 and colorectal neoplasm: The phosphatidylinositol 3-kinase/AKT/mammalian target of the rapamycin (PI3K/Akt/mTOR) signaling pathway plays a crucial role in the cell growth, proliferation and apoptosis and its dysregulations are common in a significant fraction of human malignancies, including colorectal tumors [23,24].