In the present study, we demonstrated the suppressive effect of InsP6, a natural occurring phytochemical, on the expression and activity of key components of the AKT/mTOR signaling axis including AKT1 and p70S6K1 in colon cancer cells as significant regulators of proliferation and apoptosis (Figure 9). This evidence concerns the gene AKT1 and malignant colon neoplasm.