MAPT and Parkinson disease: Tangles containing tau are also found in progressive supranuclear palsy (PSP).5 The main constituent of Lewy bodies in Parkinson's disease (PD) is an aggregated form of α‐synuclein.6 Interestingly, all of these inclusions, plaques,7, 8 tangles,7, 8, 9 and Lewy bodies7, 10 are positive for the highly conserved polypeptide ubiquitin.