Our present data showed that although no interaction between DR5 and TRAF2 was detected, DR5 directly bound to Cbl‐b and c‐Cbl, and Cbl‐b and c‐Cbl were the critical adaptors linking DR5 and TRAF2, forming the DR5‐Cbl‐b/c‐Cbl‐TRAF2 complex in gastric cancer cells. This evidence concerns the gene CBL and gastric cancer.