To further identify the effect of DR5‐Cbl‐b/c‐Cbl‐TRAF2 complex on TRAIL sensitivity, we examined the expression of these proteins in TRAIL‐resistant (BGC823 and MGC803) and TRAIL‐sensitive (HGC27 and MKN45) gastric cancer cells (Fig. 8A). This evidence concerns the gene CBLB and gastric cancer.