Given that c‐Cbl is required for EGF‐induced K48‐linked polyubiquitination of ERBB4 cytoplasmic isoforms (Meijer et al., 2013), we therefore investigated whether Cbl‐b and c‐Cbl were components of a complex that regulates caspase‐8 polyubiquitination and hence influence the sensitivity of gastric cancer cells to TRAIL. Here, TNFSF10 is linked to gastric cancer.