However, our data showed that the silencing of CUL3 or FLIP/L did not influence K48‐linked polyubiquitination of caspase‐8, and the silencing of CUL3 also did not change the interaction between TRAF2 and caspase‐8 in gastric cancer cells (Fig. S1A,B). Here, CUL3 is linked to gastric cancer.