To confirm the role of TRAF2 in polyubiquitination of caspase‐8, we silenced TRAF2 in gastric cancer cells and confirmed that TRAF2 siRNA attenuated TRAIL‐induced K48‐linked polyubiquitination of caspase‐8 in TRAIL‐resistant cells (Fig. 3C). This evidence concerns the gene TNFSF10 and gastric cancer.