In a study of obesity‐related metabolism (Lee et al., 2012), loss of Sestrin 2 caused further TOR activation in the liver, glucose intolerance and insulin resistance in obese mice, and loss of sestrins 2 and 3 resulted in insulin resistance and TOR activation in mice on a normal diet. This evidence concerns the gene SESN2 and obesity due to melanocortin 4 receptor deficiency.