Thus, mTOR activity is able to not only change intracellular metabolism, but also the behavior of the animal and global nutrient levels, raising further interesting questions about tissue‐specific mTOR activity in global homeostasis in metabolic disorders and aging, beyond the similarly organism‐wide effects mTOR signaling has in liver (Cornu et al., 2014; Lamming et al., 2014) and fat tissues (Polak et al., 2008; Cybulski et al., 2009; Kumar et al., 2010). This evidence concerns the gene MTOR and Other metabolic disease.