ANGPTL4 is expressed under sensitive transcriptional control of FA and Peroxisome proliferator-activated receptor (PPAR) which is part of a feedback mechanism to protect cells against lipotoxicity.5 Therefore plasma ANGPTL4 levels correlate strongly with FFA levels.15 On the other hand, recent findings have revealed a critical role for ANGPTL4 in cancer growth and progression, promoting the metastatic processes of melanoma cells and breast tumour cells.30 The gene discussed is ANGPTL4; the disease is cancer.