Some other benefits that result from the loss of PCSK9 expression are the reduced incidence of inflammation,7 sepsis,73 and tumor metastasis74 In addition, the observed aorta and vascular calcification in FH patients was reproduced in Ldlr KO mice and Pcsk9 KO are protected, while PCSK9 overexpression exacerbates the phenotype.75 This is in part due to an inflammatory response to the formation of cholesterol crystals in hypercholesterolemic conditions that can be reversed by the administration of anti-inflammatory mAbs to Interleukin-1β.76 The gene discussed is PCSK9; the disease is calcification.