C4B and atherosclerosis: High TG and CH concentrations in large VLDL/CM as well as low TG and CH concentrations in large HDL particles as observed in subjects of the TB study may reflect an unfavorable metabolic condition since large VLDL particles have been related to increased risk of atherosclerosis (Rizzo et al., 2008; Wurtz et al., 2011) and CVD (Arsenault et al., 2009).