When comparing the LP distribution (based on the data from LipoSEARCH) from the TB cohort of this study with the healthy, hypercholesterolemic Mihaleva cohort from our previous study (Figure 1; Mihaleva et al., 2014), we observed lower HDL-CH in the larger HDL particles (HDL15, HDL16, HDL17), yet not in the smaller HDL particles (HDL18, HDL19, HDL20). This evidence concerns the gene C4B and tuberculosis.