Indeed, in both SS and SH cells, we found a condition of oxidative stress as indicated by the increase in (i) the cellular level of MDA, marker of lipid peroxidation; (ii) the extracellular level of 8-OHdG, marker of oxidative damage, which is increased in patients with NASH with respect to SS and it was related to grade of inflammation; and (iii) the specific activity of catalase, the main antioxidant enzyme. The gene discussed is CAT; the disease is metabolic dysfunction-associated steatohepatitis.