For example, in children with TS typically due to a mutation of Tsc1 gene (encoding for the protein hamartin) or Tsc2 gene (encoding for the protein tuberin) (Curatolo et al., 2015), early seizure onset is associated with a high risk for ASD (Numis et al., 2011, van Eeghen et al., 2012). This evidence concerns the gene TSC2 and Timothy syndrome.