LDLR and central nervous system cancer: Consequently, LDLR is overexpressed in human glioma cells compared to surrounding normal brain tissue.19 Recently, a limited number of studies exploited this LDLR overexpression for the delivery of apoE3-vitamin D3 nanoparticles and resveratrol, curcumin or DNA-loaded apoE3-HDL to glioblastoma cells.20–23 Though these studies demonstrated effective drug delivery in vitro, more extensive exploration of targeting specificity in vitro and in vivo is needed to further validate the utility of apoE3 nanoparticles for glioblastoma drug delivery.