This family of proteins play a pivotal role in the regulation of apoptosis,36 play a major role in cancer development/progression37 and represent key targets for anticancer drug-discovery38 The regulation of apoptosis exploits varying specificity and selectivity of pairwise interactions within the Bcl-2 family interactome (Fig. 1a).39,40 The canonical structural motif involves a BH3 domain from one Bcl-2 family member adopting a helical conformation and binding to a BH3 binding cleft of another partner (Fig. 1b). This evidence concerns the gene BCL2 and cancer.