TNF and neoplasm: Adipose tissue can favor tumor growth and development by producing anti- and proinflammatory mediators in a deregulated manner. Proinflammatory cytokines, such as IL-6 and TNF-α, are secreted, promoting cell proliferation and angiogenesis. Other cytokines, such as IL-13, IL-10, and TGF-β are also produced and their role is to maintain the tumor, regenerating tissues, and inhibit anticancer immune cells recruitment