Activated T cells in vitro induce MDSC function through IL-10; these MDSC secrete ARG-1 and IDO and express PD-L1 and MHC-II, leading to upregulation of PD-1 and LAG-3 on T-cells, promoting an immunosuppressive tumor microenvironment (50). The gene discussed is PDCD1; the disease is neoplasm.