Regarding ICKB biomarkers at the local level, an association of PD-L1 expression in pretreatment tumor biopsies with objective response to anti-PD-1/PD-L1 therapy has been observed given the constant finding that PD-L1 expression is enriched in anti-PD-1/PD-L1 therapy responders in several tumors (74). This evidence concerns the gene CD274 and neoplasm.