For example, Dickkopf1 (DKK-1, ENSG00000107984) acts as a new biomarker in human breast cancer (Liu J.T. et al., 2017), and it also exhibits transcriptional repression by epigenetic inactivation in specific cervical cancer cell lines, thus it may contribute to the constitutive activation of the Wnt signaling pathway in cervical carcinogenesis (Lee et al., 2008). The gene discussed is DKK1; the disease is breast carcinoma.