B-2 cells worsen insulin sensitivity through their production of IgG (Winer et al., 2011) while B-1 derived natural IgM and regulatory B cell (Bregs)-derived anti-inflammatory cytokine interleukin −10 (IL-10), attenuate adipose tissue inflammation, glucose intolerance, and improve metabolic syndrome in diet induced obese mice and humans (Nishimura et al., 2013; Harmon et al., 2016). The gene discussed is CD40LG; the disease is metabolic syndrome.