CD40LG and atherosclerosis: In contrast, B-1 cells, the major source for natural IgM secretion in the body (Corte-Real et al., 2009; Holodick et al., 2010; Choi et al., 2012), produce IgM to OSE on OxLDL and provide innate immune protection from diet-induced atherosclerosis in mice (Kyaw et al., 2011; Rosenfeld et al., 2015).