Oral administration of the same extract (100 mg/kg/day) to BALB/c nude mice bearing MDA-MB-453 cell xenografts significantly reduced tumor growth and suppresses angiogenesis by lowering the expression of angiogenesis factors matrix metallopeptidase-9, matrix metallopeptidase-2, and urokinase plasminogen activator in the tumor tissue. The gene discussed is MMP2; the disease is neoplasm.