The anthocyanins inhibited migration and invasion of MDA-MB-453 cells (HER2+), suppressed activation of rapidly accelerated fibrosarcoma, mitogen-activated protein kinase (MEK), and c-Jun N-terminal kinase (JNK), as well as downregulated secretion of matrix metalloproteinase 2 (MMP2) and MMP9. Here, WNK2 is linked to fibrosarcoma.