More, recently, there have been two cases of autosomal dominant inheritance of KIF1A mutation; a de novo variant in the KIF1A motor domain (p.S69L) was transmitted dominantly from father to son with pure form of HSP, and the same heterozygous variant of KIF1A was identified in a family with a dominant segregation pattern of pure HSP22,23. The gene discussed is KIF1A; the disease is hereditary spastic paraplegia.