Out of >3,000 known compounds, the only class of metabolites that consistently correlated positively with obesity across all three high fat diets (CO, SO + CO, and PL + CO) were the oxylipins of both ω-6 LA and ω-3 ALA generated by the CYP/sEH pathway. The gene discussed is PPIG; the disease is obesity due to melanocortin 4 receptor deficiency.