NFATC1 and B-cell chronic lymphocytic leukemia: While whole genome sequencing of human CLL samples provided no evidence for inactivating mutations in the regulatory region of the NFAT2 gene or of other components of the Calcineurin-NFAT signalling pathway, several lines of evidence point to epigenetic changes in the NFAT2 promotor region as a potential mode of downregulation of this transcription factor49.