In the context of cancer, NFAT2 is overexpressed and constitutively activated in a subset of patients with human CLL23, 24, and is involved in maintaining lymphoma cell survival and counteracting apoptosis in B cell lymphomas by regulating the expression of survival factors such as CD40L and BLYS25, 26. Here, NFATC1 is linked to B-cell non-Hodgkin lymphoma.