Constitutive phosphorylation of ERK1/2 in the absence of AKT activation, constitutive phosphorylation of MEK1/2 and NFAT2 overexpression were described to be associated with attenuated BCR signalling upon αIgM treatment in a subset of human CLL patients11. The gene discussed is AKT1; the disease is B-cell chronic lymphocytic leukemia.