CBLB and B-cell chronic lymphocytic leukemia: In anergic CLL, tonic stimulation of the BCR induces the recruitment of LCK and the activation of NFAT2, which subsequently translocates to the nucleus to induce the transcription of several anergy-associated genes including Cbl-b, Grail, Egr2 as well as Lck (Fig. 8, left panel).