To investigate whether β-catenin activation plays a critical role in Kindlin-2-induced HCC cell migration and invasion, SMMC7721 cells with stable ectopic Kindlin-2 expression were transiently transfected with β-catenin siRNA or treated with ICG-001, the inhibitor of Wnt/β-catenin/TCF-mediated transcription. Here, HNF4A is linked to hepatocellular carcinoma.