Our data showed no difference in E-cadherin expression between Kindlin-2 knockdown and control cells, however, Kindlin-2 knockout induced an increase in E-cadherin expression, while Kindlin-2 overexpression caused a decrease in E-cadherin expression indicating Kindlin-2 had an inhibitory effect on E-cadherin expression in HCC. This evidence concerns the gene FERMT2 and hepatocellular carcinoma.