Dlk deficiency, an upstream regulator of JUN in RGCs, and Ddit3 deficiency both provided some protection to RGC somas and axons in an acute intraocular pressure elevation mouse model of glaucoma [34, 36] Recently, we showed deficiency in Jun does not prevent axonal degeneration in a chronic ocular hypertensive mouse model of glaucoma, though it does provide some protection to RGC somas [54]. Here, DDIT3 is linked to glaucoma.