CK2 also strongly supports the activity of important signaling cascades, such as the NF-κB, in breast cancer [56] as well as in multiple myeloma, lymphoma [16] and leukemia [54], Wnt-β-catenin, [57], Hedgehog in pleural mesothelioma [58], and STAT3-dependent signaling in solid and in hematological tumors [34]. This evidence concerns the gene NFKB1 and plasma cell myeloma.