Indeed, IBP-2 was previously described as an inducer of proliferation in glioma cells via integrin β1/ERK signaling [45], and MYDGF is involved in cells survival as a paracrine-acting protein and also in inhibition of cell apoptosis in a PI3K/AKT-dependent signaling pathway [46, 47]. The gene discussed is IGFBP2; the disease is central nervous system cancer.