On the other hand, the upregulation of SPARC-like protein 1, reported to inhibit pancreatic cancer cell invasion [50], and TIMP-2, a tissue inhibitor of metalloproteinases that inhibits endothelial cell migration [51] and reduces migration and invasion of breast cancer cells [52], fits well with the decreased migration capacity we found in GBM cells exposed to primed CM. Here, SPARCL1 is linked to familial pancreatic carcinoma.