The analysis with adjustments for traditional coronary risk factors and concomitant drug use revealed that the CAD (+) DM (+) group was the only group exhibiting a significant and independent variable for a LDL-C/apoB ratio of less than 1.2, both in the overall cohort (Fig. 2), and in the subgroup of patients with serum LDL-C levels of less than 100 mg/dL (data not shown). The gene discussed is APOB; the disease is coronary artery disorder.