APOB and coronary artery disorder: Due to its observational design, we were unable to establish a causal relationship in this study, but the results of the 2 studies with different (cross-sectional and longitudinal) designs taken together strongly suggest an association between increased levels of TRL-related markers and decrease of the LDL-particle size in patients with disordered TG metabolism; thus, the LDL-C/apoB ratio may serve as a useful predictor of the future development of CAD.