Earlier studies provided strong evidence that ovarian follicles lacking FSH or FSH receptors fail to progress to a preovulatory stage, resulting in infertility [36], and expression of the LHCGR at relatively high levels in granulosa cells was required for preovulatory follicles to respond to the midcycle surge of LH that promotes ovulation, oocyte maturation, and corpus luteum formation [37]. This evidence concerns the gene PLOD1 and Infertility.