SNCA and Parkinson disease: These findings are consistent with and extend previous observations in other models and in Parkinson’s disease brain that reduced GCase activity results in increased alpha-synuclein levels (Enquist et al., 2007; Manning-Boĝ et al., 2009; Cullen et al., 2011; Mazzulli et al., 2011; Sidransky and Lopez, 2012; Sardi et al., 2011, 2013; Xu et al., 2011, 2014; Cleeter et al., 2013; Osellame et al., 2013; Fishbein et al., 2014).