Accumulation of alpha-synuclein phosphorylated at serine 129 (S129) has been shown in the brains of patients with Parkinson's disease, where the phosphorylated protein consists of up to 90% of total alpha-synuclein within Lewy bodies (Sato et al., 2013; Oueslati, 2016). Here, SNCA is linked to Parkinson disease.