The transcriptional complex is composed of Hippo pathway effectors (TAZ/YAP/TEAD) and members of the transforming growth factor-β (TGF-β) pathway (SMAD2/3) that are recruited to the UCA1 promoter and synergistically induce its expression in breast cancer cells after TGF-β treatment [45, 47]. This evidence concerns the gene UCA1 and breast cancer.