Recent studies have uncovered several dysregulated circRNAs, including hsa_circ_001059, hsa_circ_000167, hsa_circ_0067934, and cir-ITCH, in esophageal squamous cell carcinoma (ESCC), which is the seventh most common cause of cancer related death in American Men [82–84]. Here, ITCH is linked to esophageal squamous cell carcinoma.