EGFR and non-small cell lung carcinoma: In a phase I/II study of rociletinib in EGFRm+ NSCLC patients who had progressed during EGFR TKI therapy, ORR and mPFS were 59% and 13.1 months, respectively, in 46 T790M-positive patients, and 29% and 5.6 months, respectively, in 17 T790M-negative patients.