Knockdown of Rab25 expression by siRNA / shRNA transfection inhibited in vitro cell growth of renal cell carcinoma cells (786-O and A-498) [16], prostate cancer cells (LNCaP) [22] and hepatocellular carcinoma cells (Bel7402 and SK-Hep-1) [45]. This evidence concerns the gene RAB25 and hereditary clear cell renal cell carcinoma.