As CDK2 is associated with multiple cancers, like breast cancer [77], colorectal cancer [78], non-small cell lung cancer (NSCLC) [79], hence, circ-Foxo3 also carry out functions in cancers above by forming circ-Foxo3-p21-CDK2 ternary complex. The gene discussed is CDKN1A; the disease is non-small cell lung carcinoma.