And cir-ITCH as miR-7, miR-17 and miR-214 sponges may have a tumor suppressive role in esophageal squamous cell carcinoma (ESCC) [12] while cir-ITCH as miR-7 and miR-214 sponges takes part in lung cancer. This evidence concerns the gene ITCH and esophageal squamous cell carcinoma.