Resveratrol not only reduces oxidative stress by decreasing the levels of ROS, delaying the process of renal fibrosis and reducing glomerular injury and proteinuria in the model of membranous nephropathy and diabetic nephropathy [105, 106], but also significantly decreases the transcription activity of NF-κB and reduces the secretion of IL-1β, IL-6, MCP-1, TNF-α, and other SASP components, ultimately delaying the process of renal ageing [107]. This evidence concerns the gene TNF and renal fibrosis.