TGFB1 and renal fibrosis: The hypomethylation of certain genes, especially key renal transcription factors (Hepatocyte nuclear factor, HNF; Transcription factor AP, TCFAP; Sine oculis homeobox homolog 2, SIX2), has been shown to enhance the baseline expression levels of TGF-β, which participates in renal fibrosis [42].