In CKD, such as IgA nephropathy, membranous nephropathy, focal segmental glomerular sclerosis, minimal change disease, diabetic nephropathy, unilateral ureteral obstruction and even in Renal transplantation, the expression levels of senescence-associated β-galactosidase (SA-β-gal) and cell cycle inhibitor p16 protein were significantly increased in the glomeruli, tubules and interstitium, suggesting that the process of cellular senescence occurs in CKD [6–12]. Here, CDKN2A is linked to chronic kidney disease.