PLEC and pancreatic intraductal papillary-mucinous neoplasm: Plectin-1 is known to distinguish malignant intraductal papillary mucinous neoplasm (IPMN) from the benign IPMN, and also distinguish from PanIN I/II to PanIN III and PDACs.[19, 21] Further study about the diagnostic role of Plectin-1 in differentiating malignant IPMN, PanIN III, and PDAC with EUS-FNA samples is warranted.