VDR and pancreatic neoplasm: In addition to the above-mentioned mechanisms, vitamin D could markedly reduce inflammation and fibrosis in pancreatic tumor stroma and then induced stromal remodeling and increased intratumoral chemotherapy drug compared to chemotherapy alone because the VDR expressed in pancreatic tumor stroma acted as a master transcriptional regulator of pancreatic stellate cells to reprise the quiescent state [50].