KLK3 and prostate cancer: Similar result was observed in prostate cancer, and a double-blind randomized phase II study by Beer et al. demonstrated that high-dose calcitriol plus docetaxel could produce 58% prostate-specific antigen decline (>50% confirmed 4weeks later) and was associated with improved overall survival (HR=0.6, 95% CI=0.45–0.97) [49].