CDKN2A and renal cell carcinoma: The pooled OR from seven studies and from three studies suggested that p16INK4A and p14ARF promoter methylation was not significantly correlated with tumor grade in RCC (OR = 1.20, 95% CI = 0.58-2.45, P = 0.625; OR = 2.13, 95% CI = 0.96-4.75, P = 0.063, respectively) (Table 4).