The pooled sensitivity of NSE for detecting SCLC was 0.688 (95%CI: 0.627-0.743) (Figure 4), the specificity was 0.921(95%CI: 0.890-0.944) (Figure 5), the positive likelihood ratio (PLR) was 8.744 (6.308-12.121), the negative likelihood ratio (NLR) was 0.339 (95%CI: 0.283, 0.405), and diagnostic odds ratio (DOR) was 25.827 (95%CI: 17.490- 38.136). The gene discussed is ENO2; the disease is small cell lung carcinoma.