In the present study, we found that the methylation level of the CG-7.8.9 unit of GATA3, CG-2 site of IL-4 as well as CG-2.3.4.5 and CG-10.11 units of TGF-β was significantly elevated in CD4+T cells from active BD patients. This evidence concerns the gene TGFB1 and Behcet disease.