Due to the strong correlation between high miR-708 levels and low DKK3 expression in the adult B-ALL samples evaluated in this study, aberrant miR-708 expression might serve as a novel mechanism for the activation of Wnt/β-catenin signaling in adult B-ALL, and this mechanism may be equally important for methylation in this context. Here, DKK3 is linked to precursor B-cell acute lymphoblastic leukemia.