The results showed that there were no differences among the Wor+T4, Per+T4, and Rap+T4 groups at 0 h and 24 h in the expression of PI3-K, PI3-P, AKT, TSC2, mTOR, p70S6K and 4E-BP1 in A549 lung cancer cells. Here, TSC2 is linked to lung cancer.