D'Incecco et al. reported that in patients with non-small cell lung cancer (NSCLC) treated with epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs), the response rate, time to progression, and overall survival (OS) were significantly better in PD-L1-positive tumors [10]. The gene discussed is CD274; the disease is non-small cell lung carcinoma.