TP53 and cancer: Considering pediatric ACTs and adult ACTs show different genetic backgrounds, such as TP53 mutations, as well as different molecular mechanism involved in tumorigenesis [5, 7], and oncogenes and tumor suppressors are important regulators of cancer cell metabolism [42], it is not surprising the expression of metabolism-related proteins in pediatric ACTs found in the present study shows some differences, when compared with a previous study with adult ACTs [30].