Finally, CAIX, a pH regulator upregulated in a variety of cancers, including adult adrenocortical carcinomas [30], showed similar expression between benign and malignant samples, suggesting other pH regulator, such as CAXII, should be involved in the acid-resistant phenotype associated with the hyperglycolytic phenotype depicted by GLUT1 overexpression. The gene discussed is SLC2A1; the disease is cancer.