HK1 and carcinoma: Additionally, comparative studies in adult ACTs showed carcinomas, in opposition to adenomas, present biochemical markers indicative of increased glycolysis (such as lactate) [39], as well as increased levels of GLUT1 [40] and aldolase A, also a glycolytic enzyme, and decreased levels of proteins related to mitochondrial activity [41], also suggesting a metabolic reprogramming compatible with the Warburg effect.