DRAM1 and cardiac hypertrophy: Yi et al. [24] also found that miR-199a-5p suppressed autophagy in MCF7 cells by inhibiting DRAM1 and BECN1. Most recently, Li et al. [25] reported miR-199a's suppressive role in CMs autophagy during cardiac hypertrophy through down-regulating of GSK3β and then activating mTOR.