The major finding of this study is that the pretreatment serum lactate level is a more valuable prognostic biomarker than other biomarkers, including neuronal (NSE, S100β, and GFAP) and nonneuronal (NGAL and LDH) biomarkers, in patients with supratentorial primary brain tumors undergoing tumor resection. This evidence concerns the gene ENO2 and brain neoplasm.