Transcriptional hallmarks of human HCC include: 1) disturbances in cell cycle regulation as a result of RB1 silencing or TP53 mutations; 2) sustained angiogenesis resulting from overexpression of VEGFA, PDGFA, or ANGPT2; 3) evasion of apoptosis; and 4) reactivation of TERT [10]. This evidence concerns the gene RB1 and hepatocellular carcinoma.