CCND1 and hepatocellular carcinoma: It was further demonstrated that pHCC cells closely parallel human HCC at the transcriptomic level in terms of TP53 dependent cell cycle regulation and CCND1 overexpression, increased angiogenesis through elevated PDGFA and ANGPT2 expression, evasion of apoptosis, reactivation of TERT allowing uncontrolled cellular replication, and Wnt signaling activation.