Master regulators of reduced gene expression were highly conserved, with 8 TFs (EP300, HNF4G, HDAC2, NR2F2, FOXA1, HNF4A, CEBPB, and FOXA2) identified in the Oncopig and all human HCC cell lines (Table 1). Here, FOXA1 is linked to hepatocellular carcinoma.