In addition, previous reports showed that although DEPDC1 knockdown resulted in obvious loss-of-function phenotype, introduction of DEPDC1 expression construct into NIH3T3 cells could not enhance the growth of cells, and DEPDC1 overexpression caused no enhancement of cell migration and invasion potentials in bladder cancer cells [8, 9]. The gene discussed is DEPDC1; the disease is urinary bladder cancer.