Our results indicate that in these ovarian cancer cells, glucose deprivation causes inhibition of ovarian cancer cell growth through the induction of G1 phase cell cycle arrest and apoptosis as seen with augmented Annexin-V expression, along with decreased expression of CDK4, cyclin D1, MCL-1, BCL-2 and increased p21 expression. The gene discussed is CCND1; the disease is ovarian cancer.