For MTHFR rs9651118 T>C polymorphism, we found MTHFR rs9651118 CC genotypes might be associated with an increased risk of colon cancer (CC vs. TT+TC: adjusted OR = 1.53, 95% CI = 1.01–2.31, P = 0.044). The gene discussed is MTHFR; the disease is colonic neoplasm.