Based on the specificity and sensitivity of CDH17 and SATB2 for colonic and rectal tumors and their low expression in primary pulmonary tumors, we chose to compare CDH17, SATB2, CK7, napsin A, thyroid transcription factor (TTF-1), CK20, CDX-2, and villin expression in PEAC and metastatic colorectal adenocarcinoma. Here, CDH17 is linked to rectal neoplasm.