Although the precise mechanism of increased GLDC in HER2-positive cancers is unknown, a 20-fold increase in GLDC expression was seen in MCF10A cells after oncogenic transformation by KRASG12D, PIK3CAE545K, or MYCT58A [36], suggesting that HER2-positive cancer may be driven by certain HER2 oncogenes. This evidence concerns the gene ERBB2 and cancer.