Jiliang Feng et al based on the expression phase and spectrum of cytokeratin 19 (CK19) and glypican 3 (GPC3) had sub-classified HCC into CK19+/GPC3+, CK19−/GPC3+, and CK19−/GPC3−phenotypes, which roughly corresponded to HCC subtype transform from the HPC, immature hepatocyte, and terminal differentiated hepatocyte, respectively. The gene discussed is KRT19; the disease is hepatocellular carcinoma.