GPC3 and neoplasm: There were high statistical significance in the RFS rates between the groups of the modified bi-classifications of the histological grading, CK19/GPC3 expression pattern and tumor number (well+moderately vs poorly: P<0.01; CK19−/GPC3+ and CK19−/GPC3−vs CK19+/GPC3+: P<0.01; single tumor vs 2 and 3 tumors: P<0.01).